Holly, a 5-year-old girl, is showing atypical behaviours and experiencing difficulties in social interaction and communication. Her parents are concerned and decide to take her for a diagnostic evaluation. During the evaluation, the healthcare professional suspects that Holly might have Autism Spectrum Disorder (ASD) based on her symptoms. According to lecture, which of the following is associated with Autism Spectrum Disorder (ASD)?

I) An under abundance of synapses caused by excess synaptic pruning
II) An overabundance of synapses and inefficient synaptic pruning
III) A reduced number of reactive astrocytes
IV) A reduced number of reactive microglia